Characterization of a serum inhibitor of MLC reactions.

摘要: Serum from a healthy multigravida female was found to inhibit most MLC combinations tested. Attempts characterize the inhibitory factor have revealed that it is not lymphocytotoxic, destroyed by heat or directed against HL-A specificities. The activity segregates with 7S IgG fraction, effective in very small concentrations and consistently fails between cells serum donor those one other unrelated individual. blocking effect on occurs during first 6–9 hr of incubation. Inhibitory persists donor's 16 months after delivery her last child. An attempt utilize minimize an expected graft-versus-host (GVH) reaction following bone marrow transplantation daughter child's father resulted neither GVH nor `take' graft. possible effects grafted are discussed. While recognition site for remains unknown, appears involve T-cell receptor.