Maternal—Fetal relation: II. Further characterization of an immunologic blocking factor that develops during pregnancy

摘要: Abstract An IgG blocking factor previously described to be present in the serum of normal multigravid women inhibits production macrophage migration inhibitory (MIF) by maternal lymphocytes responding paternal antigens. In study, this was detected primigravid during 12–26 weeks gestation. The found block MIF as well lymphocyte proliferation induced an allogeneic stimulus. Blocking activity at about same time gestation when measured either assay. addition, fractions isolated from placental eluates were suppress extent activity. Like activity, suppressed a specific manner (autologous but not homologous IgG). attempt study antigenic nature trophoblast, we observed that solubilized trophoblast membranes able stimulate mononuclear cells produce MIF; response antigen autologous stimulatory. HLA-A,B,C and DR typing gravid with idiopathic spontaneous abortions revealed similar degrees matching mismatching both groups subjects for these There no significant increase or decrease any HLA-A,B,C, antigens group chronic aborters. Thus, biologic significance antibody develops pregnancy has been further characterized its role maintenance normal-term discussed.