Growth hormone and prolactin regulate human neural stem cell regenerative activity.

摘要: We have previously shown that the growth hormone (GH)/prolactin (PRL) axis has a significant role in regulating neuroprotective and/or neurorestorative mechanisms brain and these effects are mediated, at least partly, via actions on neural stem cells (NSCs). Here, using NSCs with properties of neurogenic radial glia derived from fetal human forebrains, we show exogenously applied GH PRL promote proliferation absence epidermal factor or basic fibroblast factor. When to differentiating NSCs, they both induce neuronal progenitor proliferation, but only proliferative glial progenitors. Both also NSC migration, particularly higher concentrations. Since activates receptors, hypothesized some may be mediated latter. Migration studies receptor-specific antagonists confirmed signals receptor migration. Mechanisms signaling however, remain elucidated. In summary, complex stimulatory modulatory activity as such injury-related recovery processes brain.