Cell-surface glycoprotein of oligodendrocyte progenitors involved in migration.

摘要: Myelination by oligodendrocytes in the CNS involves migration to and recognition ensheathment of axons. These distinct developmental phases myelination are assumed involve interplay a precisely regulated set cell adhesion molecules expressed both neurons glial cells. remain largely unelucidated. In this paper we have identified large (330 kDa) glycoprotein murine oligodendrocyte progenitor cells vitro vivo that is downregulated as mature. Antigen-positive purified panning develop into myelin-associated glycoprotein-positive also adhere cultured neurons. Polyclonal antibodies directed against protein reduce The observations suggest AN2 antigen may play role early stages myelination.