Pedunculopontine stimulation alters respiration and increases ACh release in the pontine reticular formation.

摘要: The present study examined the hypothesis that cholinergic neurons in pedunculopontine tegmental nucleus (PPT) can cause release of acetylcholine (ACh) pontine reticular formation and contribute to respiratory depression. In vivo microdialysis gigantocellular field (FTG) was performed 10 adult male cats while respiration being measured. four intact, unanesthetized these measurements were obtained during states quiet wakefulness rapid eye movement (REM) sleeplike state caused by FTG microinjections carbachol. results demonstrate a simultaneous time course enhanced ACh rate six barbiturate-anesthetized similar PPT regions containing NADPH-positive electrically stimulated. stimulation increased Together, findings are consistent with causal relationship between