Chronic obstructive pulmonary disease severity and cardiovascular outcomes.

作者: Suellen M. Curkendall , Stephan Lanes , Cynthia de Luise , Mary Rose Stang , Judith K. Jones

DOI: 10.1007/S10654-006-9066-1

关键词:

摘要: Objective: To identify predictors of chronic obstructive pulmonary disease (COPD) severity and assess the relation between COPD risk cardiovascular outcomes. Study design setting: A cohort patients with diagnosed treated was compiled from Saskatchewan Health longitudinal databases. We used multivariate mod- eling to hospitalization for as an indicator severity, we model characterize according quintiles severity. These levels were independent variables in models Results: Determinants included emphysema, recent nebulizer use, home oxygen services, corticosteroid fre- quent bronchodilator pneumonia prior exacerbation. The 20% highest 1.27 (CI: 1.07-1.50) times more likely have arrhythmia, 1.25 1.07- 1.46) ischemic heart disease, 1.38 1.11-1.71) angina, 2.28 1.95-2.66) con- gestive failure, 1.63 1.22-2.16) die causes than least severe patients. Conclusions: Patients COPD, defined by our model, had higher morbidity mortality less COPD.

参考文章(26)
Joan B. Soriano, William C. Maier, George Visick, Neil B. Pride, Validation of general practitioner-diagnosed COPD in the UK General Practice Research Database. European Journal of Epidemiology. ,vol. 17, pp. 1075- 1080 ,(2001) , 10.1023/A:1021235123382
Winanne Downey, Patricia Beck, Mary McNutt, Mary Rose Stang, William Osei, Jim Nichol, Health Databases in Saskatchewan John Wiley & Sons, Ltd. pp. 325- 345 ,(2002) , 10.1002/0470842555.CH20
Samy Suissa, Effectiveness of inhaled corticosteroids in chronic obstructive pulmonary disease: immortal time bias in observational studies. American Journal of Respiratory and Critical Care Medicine. ,vol. 168, pp. 49- 53 ,(2003) , 10.1164/RCCM.200210-1231OC
D. W. Cockcroft, M. J. Baker, M. McNutt, B. Habbick, Recent trends in the use of inhaled beta 2-adrenergic agonists and inhaled corticosteroids in Saskatchewan. Canadian Medical Association Journal. ,vol. 153, pp. 1437- 1443 ,(1995)
Gary D. Friedman, Arthur L. Klatsky, A.B. Siegelaub, Lung Function and Risk of Myocardial Infarction and Sudden Cardiac Death New England Journal of Medicine. ,vol. 294, pp. 1071- 1075 ,(1976) , 10.1056/NEJM197605132942001
G. Engström, P. Lind, B. Hedblad, P. Wollmer, L. Stavenow, L. Janzon, F. Lindgärde, Lung Function and Cardiovascular Risk Relationship With Inflammation-Sensitive Plasma Proteins Circulation. ,vol. 106, pp. 2555- 2560 ,(2002) , 10.1161/01.CIR.0000037220.00065.0D
Suellen M. Curkendall, Jingping Mo, Dale B. Glasser, Mary Rose Stang, Judith K. Jones, Cardiovascular disease in patients with schizophrenia in Saskatchewan, Canada. The Journal of Clinical Psychiatry. ,vol. 65, pp. 715- 720 ,(2004) , 10.4088/JCP.V65N0519
Marta L. Render, Aaron S. Weinstein, Alvin S. Blaustein, Left Ventricular Dysfunction in Deteriorating Patients With Chronic Obstructive Pulmonary Disease Chest. ,vol. 107, pp. 162- 168 ,(1995) , 10.1378/CHEST.107.1.162
M. Stang, D. K. Wysowski, D. Butler-Jones, Incidence of lactic acidosis in metformin users. Diabetes Care. ,vol. 22, pp. 925- 927 ,(1999) , 10.2337/DIACARE.22.6.925
Suellen M. Curkendall, Cynthia deLuise, Judith K. Jones, Stephan Lanes, Mary Rose Stang, Earl Goehring, Dewei She, Cardiovascular Disease in Patients with Chronic Obstructive Pulmonary Disease, Saskatchewan Canada : Cardiovascular Disease in COPD Patients Annals of Epidemiology. ,vol. 16, pp. 63- 70 ,(2006) , 10.1016/J.ANNEPIDEM.2005.04.008