Integrin and growth factor receptor alliance in angiogenesis.

摘要: A sequence of events in vascular and stromal cells maintained a highly coordinated manner regulates angiogenesis tissue remodeling. These processes are mediated by the ability to respond environmental cues activate surface integrins. Physiological pathological biology dependent on specificity important signaling mechanisms that activated through association between growth factors, their receptors, integrins, specific extracellular matrix ligands. large body evidence from vitro vivo models demonstrates importance coordination signals environment activates tyrosine kinase receptors integrins order regulate angiogenic vivo. In addition complex formation factor factors cytokines also directly interact with depending upon concentration levels environment, differentially integrin-related processes. Recent studies number laboratories including ours have provided novel insights into involvement many improve our existing knowledge cross-talk regulation angiogenesis. this review, focus will be updating recent developments field integrin-growth receptor associations implications