Paraneoplastic Pemphigus and Autoimmune Blistering Diseases Associated with Neoplasm: Characteristics, Diagnosis, Associated Neoplasms, Proposed Pathogenesis, Treatment

摘要: Autoimmune paraneoplastic and neoplasm-associated skin syndromes are characterized by autoimmune-mediated cutaneous lesions in the presence of a neoplasm. The identification these provides information about underlying tumor, systemic symptoms, debilitating complications. recognition is particularly helpful cases presenting as first sign malignancy, malignancy can be treated timely manner. bullous blister formation due to an autoimmune response components epidermis or basement membrane context clinical manifestations, histopathology immunopathology findings, target antigens, associated neoplasm, current diagnostic criteria, understanding pathogenesis, treatment options for selection four diseases reviewed. Paraneoplastic pemphigus manifests with clinically distinct painful mucosal erosions polymorphic lesions, often lymphoproliferative In contrast, pemphigoid neoplasm presents large tense subepidermal bullae skin, mild involvement, but without unique features. Mucous disorder chronic subepithelial blisters that evolve into ulcerations heal scarring, involves stratified squamous surfaces. Linear IgA dermatosis annularly grouped pruritic papules, vesicles, along extensor surfaces elbows, knees, buttocks. Physicians should aware manifest similar features compared non-neoplastic counterparts.