The Drosophila RNA-binding protein Lark is required for localization of Dmoesin to the oocyte cortex during oogenesis.

摘要: The RNA-binding protein Lark has an essential maternal role during Drosophila oogenesis. Elimination of expression results in defects cytoplasmic dumping and actin cytoskeletal organization nurse cells. function this is dependent on the activity one or more N-terminal domains. Here, we report identification Dmoesin (Dmoe) as a candidate RNA target In addition to cells lark mutant ovaries, observed mislocalization posteriorly localized mRNAs including oskar germ cell less developing oocyte. Anteriorly dorsally were not affected. addition, displacement cytoskeleton from oocyte plasma membrane. These phenotypes are reminiscent mutations Dmoe suggested that maybe potential Lark. We significant decrease associated with membrane no changes localization within Evidence for association between moe oogenesis comes microarray-based Ribonomics approach identify targets. Thus, our provide evidence it likely regulates either splicing translation RNA.