Combination Therapy of 3-Methylcholanthrene-induced Mammary Carcinoma in Rats: Effect of Chemotherapy, Ovariectomy, and Food Restriction

摘要: The growth of mammary carcinoma induced by oral 3-methylcholanthrene in female Wistar rats is retarded ovariectomy and food restriction sufficient to produce 12–14% body weight loss. Estradiol benzoate (NSC 9566), 5-fluorouracil 19893), miracil D 14574), mitomycin C 26980), AB-100 37095) showed inhibitory activity. best tumor inhibition without mortality was elicited combined with restriction, estradiol benzoate.