Positron emission tomography imaging of brain tumors.

摘要: A wide variety of metabolic features brain tumors can be imaged using PET, including glucose metabolism, blood flow, oxygen consumption, amino acid and lipid synthesis. Currently, FDG is the most widely available PET tracer for body imaging imaging. Malignant tumors, like many other soft tissue show increased which reflected on FDG-PET provides information tumor grade prognosis. Compared with organ systems, presents unique challenges because high background metabolism normal gray matter structures. Coregistration MRI (or CT) images essential accurate evaluation performed routinely at authors' institution. The heterogeneous nature gliomas result in significant sampling errors when patients are biopsied primary diagnosis or recurrent disease. used to define metabolically active targets stereotactic biopsy. This turn improve diagnostic accuracy reduce number biopsy samples required. also useful evaluating residual following therapy, survey low-grade evidence degeneration into high-grade malignancy. In case suspected recurrence progression, aid defining appropriate One limitation occasional inability distinguish radiation necrosis from tumor. second that less sensitive than contrast-enhanced detecting intracranial metastases, it experience studies should not included as part routine whole-body studies. Other tracers, such 11C-methionine FCH, avidly accumulate have advantage low cortical activity. relationship between degree uptake these agents established. These tracers may specific clinical situations, however, localization treatment planning tumors.