Reconstruction of genomic rearrangements in great apes and gibbons by chromosome painting.

摘要: The homology between hylobatid chromosomes and other primates has long remained elusive. We used chromosomal in situ suppression hybridization of all human chromosome-specific DNA libraries to "paint" the establish homologies human, great ape (chimpanzee, gorilla, orangutan), gibbon karyotypes (Hylobates lar species group, 2n = 44). patterns unequivocally demonstrate high degree synteny chromosomes. Relative no translocations were detected apes, except for well-known fusion-origin chromosome 2 a 5;17 translocation gorilla. In contrast, numerous that have led massive reorganization karyotype: 22 autosomal been divided into 51 elements compose 21 autosomes. Molecular cytogenetics promises finally allow hylobatids be integrated overall picture evolution primates.