Amphetamine and vigabatrin down regulate aromatic l-amino acid decarboxylase mRNA levels
作者： Paul R. Buckland , Gillian Spurlock , Peter McGuffin
DOI: 10.1016/0169-328X(95)00182-R
关键词:
摘要: Aromatic L-amino acid decarboxylase (AADC) has previously been shown to be up-regulated at the level of its protein activity and mRNA abundance by antipsychotic drugs. Its also down-regulated dopamine agonists including amphetamine. In this study we have injected rats for up 32 days with amphetamine anti-epileptic drug vigabatrin, both which can cause psychosis similarities schizophrenia. We that AADC levels are reduced in most brain regions Cocaine other non-psychotogenic drugs had no effect paradigm. Two products enzyme implicated psychotogenesis.
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