2-Furaldehyde diethyl acetal from tender coconut water (Cocos nucifera) attenuates biofilm formation and quorum sensing-mediated virulence of Chromobacterium violaceum and Pseudomonas aeruginosa.
作者： Sivasamy Sethupathy , Chari Nithya , Shunmugiah Karutha Pandian
DOI: 10.1080/08927014.2015.1102897
关键词:
摘要: The aim of this study was to evaluate the anti-biofilm and quorum sensing inhibitory (QSI) potential tender coconut water (TCW) against Chromobacterium violaceum Pseudomonas aeruginosa. TCW significantly inhibited QS regulated violacein, virulence factors biofilm production without affecting their growth. qRT-PCR analysis revealed down-regulation autoinducer synthase, transcriptional regulator genes. Mass-spectrometric a petroleum ether extract hydrolyte that 2-furaldehyde diethyl acetal (2FDA) palmitic acid (PA) are major compounds. In vitro bioassays confirmed ability 2FDA inhibit formation factors. addition, combination PA with resulted in potent inhibition results obtained strongly suggest can be exploited as base for designing novel antipathogenic drug formulation treat mediated infections caused by P.
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