Induction of Keratinocyte Growth Factor Expression Is reduced and Delayed During Wound Healing in the Genetically Diabetic Mouse

摘要: We have recently demonstrated induction of expression several members the fibroblast growth factor family during wound healing, particularly for keratinocyte factor, which was more than 150-fold induced within 24 h after injury. To assess whether wound-healing disorders are associated with a defect in regulation, we now investigated these mitogens as well their receptors normal and wounded skin genetically diabetic db/db mice, characterized by impaired healing. demonstrate that mice is significantly reduced delayed compared to mice. Induction acidic (FGF) basic FGF earlier but 3 d injury had already returned basal levels. In contrast, elevated levels transcripts were detected first 5 wounds from Thus, FGFs seem be expressed limited fashion tissue period when re-epithelialization granulation formation normally occur. These findings provide an explanation beneficial effect exogenous treatment healing animals suggest KGF early repair may critical rapid