The Ig superfamily protein PTGFRN coordinates survival signaling in glioblastoma multiforme.

摘要: Glioblastoma multiforme (GBM) is the most malignant primary brain tumor with a median survival of approximately 14 months. Despite aggressive treatment surgical resection, chemotherapy and radiation therapy, only 3-5% GBM patients survive more than 3 years. Contributing to this poor therapeutic response, it believed that contains both intrinsic acquired mechanisms resistance, including resistance therapy. In order define novel mediators we conducted functional knockdown screen, identified immunoglobulin superfamily protein, PTGFRN. GBM, PTGFRN found be overexpressed correlate survival. Reducing expression radiosensitizes cells potently decreases rate cell proliferation growth. Further, inhibition results in significant reduction PI3K p110β phosphorylated AKT, due instability p110β. Additionally, nuclear leading decreased DNA damage sensing repair. Therefore overexpression glioblastoma promotes AKT-driven signaling growth, as well increased repair signaling. These findings suggest potential hub for aggressiveness GBM.