Investigating the potential neuroprotective effects of statins on DNA damage in mouse striatum.

摘要: We investigated the protective effect of pravastatin, simvastatin and atorvastatin on striatal DNA damage as a potential method to conserve protect nigrostriatal neurons. C57Bl/J6 mice were treated with combinations statin neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). damage, sensitivity H(2)O(2)in vitro, repair capacity was measured using single cell gel electrophoresis (comet) assay. MPTP treatment increased in striatum. Contrary expectation, statins studied here did not against H(2)O(2) induced but fact cause damage. Treatment showed significant increase levels (p < or = 0.0018) vitro significantly by pravastatin 0.0001). slightly simvastatin, (p=0.0093), decreased atorvastatin. In groups, pre-treated statins, =0.0036) 0.021), level while exhibit effect. All three administered prior MPTP, offered slight protection cells insignificantly. under experimental conditions used, baseline processes left intact because amount also increased. Oxidative however, largely exceeded extent both MPTP.