Peptide reactivity between multiple sclerosis (MS) CSF IgG and recombinant antibodies generated from clonally expanded plasma cells in MS CSF.
作者： Xiaoli Yu , Don Gilden , Laura Schambers , Olga Barmina , Mark Burgoon
DOI: 10.1016/J.JNEUROIM.2010.11.007
关键词:
摘要: We employed 19 recombinant antibodies (rAbs) generated from clonally expanded plasma cells, and native IgG cerebrospinal fluid (CSF) of three multiple sclerosis (MS) patients for panning with phage displayed random peptide libraries. Specific epitopes/mimotopes were identified characterized. Importantly, peptide-antibody interactions shared by rAbs the same patient. Three peptides strongly interacted at least one other MS CSF, but not to inflammatory CNS controls. Database searches revealed several protein candidates including stress proteins, cell surface neuronal proteins. Peptides derived candidate proteins recognized rAbs. Identification in may provide clues regarding disease-relevant antigens.
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sci-hub.se 参考文章(40)
Katherine A. McLaughlin, Kai W. Wucherpfennig, B cells and autoantibodies in the pathogenesis of multiple sclerosis and related inflammatory demyelinating diseases. Advances in Immunology. ,vol. 98, pp. 121- 149 ,(2008) , 10.1016/S0065-2776(08)00404-5
Alanna M. Ritchie, Donald H. Gilden, R. Anthony Williamson, Mark P. Burgoon, Xiaoli Yu, Karen Helm, John R. Corboy, Gregory P. Owens, Comparative analysis of the CD19+ and CD138+ cell antibody repertoires in the cerebrospinal fluid of patients with multiple sclerosis. Journal of Immunology. ,vol. 173, pp. 649- 656 ,(2004) , 10.4049/JIMMUNOL.173.1.649
M. P. Burgoon, K. M. Keays, G. P. Owens, A. M. Ritchie, P. R. Rai, C. D. Cool, D. H. Gilden, Laser-capture microdissection of plasma cells from subacute sclerosing panencephalitis brain reveals intrathecal disease-relevant antibodies Proceedings of the National Academy of Sciences of the United States of America. ,vol. 102, pp. 7245- 7250 ,(2005) , 10.1073/PNAS.0502323102
Irene Cortese, Stefania Capone, Sabina Luchetti, Riccardo Cortese, Alfredo Nicosia, Cross-reactive phage-displayed mimotopes lead to the discovery of mimicry between HSV-1 and a brain-specific protein. Journal of Neuroimmunology. ,vol. 113, pp. 119- 128 ,(2001) , 10.1016/S0165-5728(00)00398-2
Hans‐Christian von Büdingen, Melanie D. Harrer, Sandra Kuenzle, Mirjam Meier, Norbert Goebels, Clonally expanded plasma cells in the cerebrospinal fluid of MS patients produce myelin-specific antibodies. European Journal of Immunology. ,vol. 38, pp. 2014- 2023 ,(2008) , 10.1002/EJI.200737784
Gregory P. Owens, Andrew J. Shearer, Xiaoli Yu, Alanna M. Ritchie, Kathryne M. Keays, Jeffrey L. Bennett, Donald H. Gilden, Mark P. Burgoon, Screening Random Peptide Libraries with Subacute Sclerosing Panencephalitis Brain-Derived Recombinant Antibodies Identifies Multiple Epitopes in the C-Terminal Region of the Measles Virus Nucleocapsid Protein Journal of Virology. ,vol. 80, pp. 12121- 12130 ,(2006) , 10.1128/JVI.01704-06
I. Cortese, R. Tafi, L. M. Grimaldi, G. Martino, A. Nicosia, R. Cortese, IDENTIFICATION OF PEPTIDES SPECIFIC FOR CEREBROSPINAL FLUID ANTIBODIES IN MULTIPLE SCLEROSIS BY USING PHAGE LIBRARIES Proceedings of the National Academy of Sciences of the United States of America. ,vol. 93, pp. 11063- 11067 ,(1996) , 10.1073/PNAS.93.20.11063
Gregory P. Owens, Jeffrey L. Bennett, Hans Lassmann, Kevin C. O'Connor, Alanna M. Ritchie, Andrew Shearer, Chiwah Lam, Xiaoli Yu, Marius Birlea, Cecily DuPree, R. Anthony Williamson, David A. Hafler, Mark P. Burgoon, Don Gilden, Antibodies produced by clonally expanded plasma cells in multiple sclerosis cerebrospinal fluid Annals of Neurology. ,vol. 65, pp. 639- 649 ,(2009) , 10.1002/ANA.21641
Kimberly M. Winges, Donald H. Gilden, Jeffrey L. Bennett, Xiaoli Yu, Alanna M. Ritchie, Gregory P. Owens, Analysis of multiple sclerosis cerebrospinal fluid reveals a continuum of clonally related antibody-secreting cells that are predominantly plasma blasts Journal of Neuroimmunology. ,vol. 192, pp. 226- 234 ,(2007) , 10.1016/J.JNEUROIM.2007.10.009
Hans-Christian von Büdingen, Monica Gulati, Sandra Kuenzle, Katja Fischer, Tobias A. Rupprecht, Norbert Goebels, Clonally expanded plasma cells in the cerebrospinal fluid of patients with central nervous system autoimmune demyelination produce “oligoclonal bands” Journal of Neuroimmunology. ,vol. 218, pp. 134- 139 ,(2010) , 10.1016/J.JNEUROIM.2009.10.005