Clonally expanded plasma cells in the cerebrospinal fluid of patients with central nervous system autoimmune demyelination produce “oligoclonal bands”
作者： Hans-Christian von Büdingen , Monica Gulati , Sandra Kuenzle , Katja Fischer , Tobias A. Rupprecht
DOI: 10.1016/J.JNEUROIM.2009.10.005
关键词:
摘要: Clonally expanded plasma cells (cePC) and oligoclonal IgG (oligoclonal bands, OCB) in the cerebrospinal fluid (CSF) suggest an involvement of B cell mechanisms autoimmune CNS demyelination. Due to their CSF-restricted occurrence, OCB are commonly believed be products inside borders blood brain barrier. A comparison CSF Ig transcriptomes CSF-Ig proteomes recently demonstrated, that multiple sclerosis patients origin immunoglobulins. We expand these findings by applying anti-idiotypic antibodies detect specific heavy chain CDR3 idiotopes cePC-produced amongst a patient each with MS acute disseminated encephalomyelitis.
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