Novel therapy for nasopharyngeal carcinoma--where are we.

作者: Janice Tsang , Victor H.F. Lee , Dora L.W. Kwong

DOI: 10.1016/J.ORALONCOLOGY.2014.01.002

关键词:

摘要: Nasopharyngeal carcinoma (NPC) is endemic in Southern China, and the South-East Asia including Hong Kong. We still see patients recur after primary treatment with radiotherapy or chemo-irradiation. Management of nasopharyngeal remains one biggest clinical challenges. There have been breakthroughs early detection, diagnosis, multi-modality also disease monitoring for NPC. Systemic has crucial to management locally advanced metastatic With advent molecular targeted therapy personalized medicine, novel therapies based on targets NPC become focus research development over last decade. Furthermore, as tightly associated Epstein-Barr virus (EBV) infection, role tumor-associated viral antigens renders it an appealing candidate cellular immunotherapy. This a review recent evolving concerted efforts success from our translational systemic potential immunotherapy which may offer further benefit living The scientific basis latest published results relevant trials are highlighted, demonstrating ongoing battle against indeed most fascinating successes head neck oncology.

参考文章(55)
Brigette BY Ma, Terence CW Poon, KF To, Benny Zee, Frankie KF Mo, Charles ML Chan, Stephen Ho, Peter ML Teo, Phillip J Johnson, Anthony TC Chan, None, Prognostic significance of tumor angiogenesis, Ki 67, p53 oncoprotein, epidermal growth factor receptor and HER2 receptor protein expression in undifferentiated nasopharyngeal carcinoma - A prospective study Head and Neck-journal for The Sciences and Specialties of The Head and Neck. ,vol. 25, pp. 864- 872 ,(2003) , 10.1002/HED.10307
Christine Elser, Lillian L. Siu, Eric Winquist, Mark Agulnik, Gregory R. Pond, Soo F. Chin, Peggy Francis, Robin Cheiken, James Elting, Angela McNabola, Dean Wilkie, Oana Petrenciuc, Eric X. Chen, Phase II Trial of Sorafenib in Patients With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck or Nasopharyngeal Carcinoma Journal of Clinical Oncology. ,vol. 25, pp. 3766- 3773 ,(2007) , 10.1200/JCO.2006.10.2871
Brigette BY Ma, Anthony TC Chan, Systemic treatment strategies and therapeutic monitoring for advanced nasopharyngeal carcinoma. Expert Review of Anticancer Therapy. ,vol. 6, pp. 383- 394 ,(2006) , 10.1586/14737140.6.3.383
Stephen L Chan, Yan Cui, Andrew van Hasselt, Hongyu Li, Gopesh Srivastava, Hongchuan Jin, Ka M Ng, Yajun Wang, Kwan Y Lee, George S W Tsao, Sheng Zhong, Keith D Robertson, Sun Y Rha, Anthony T C Chan, Qian Tao, The tumor suppressor Wnt inhibitory factor 1 is frequently methylated in nasopharyngeal and esophageal carcinomas. Laboratory Investigation. ,vol. 87, pp. 644- 650 ,(2007) , 10.1038/LABINVEST.3700547
Brigette Ma, Edwin P. Hui, Ann King, K. F. To, Frankie Mo, Sing F. Leung, Michael Kam, Y. M. Dennis Lo, Benny Zee, Tony Mok, Anil Ahuja, Anthony T. C. Chan, A phase II study of patients with metastatic or locoregionally recurrent nasopharyngeal carcinoma and evaluation of plasma Epstein-Barr virus DNA as a biomarker of efficacy. Cancer Chemotherapy and Pharmacology. ,vol. 62, pp. 59- 64 ,(2008) , 10.1007/S00280-007-0575-8
H. Rupani, P. Busson, T. Tursz, A. Johnson, A. B. Rickinson, L. S. Young, C. W. Dawson, D. Clark, Epstein-Barr virus gene expression in nasopharyngeal carcinoma. Journal of General Virology. ,vol. 69, pp. 1051- 1065 ,(1988) , 10.1099/0022-1317-69-5-1051
R. Khanna, S. Bell, M. Sherritt, A. Galbraith, S. R. Burrows, L. Rafter, B. Clarke, R. Slaughter, M. C. Falk, J. Douglass, T. Williams, S. L. Elliott, D. J. Moss, Activation and adoptive transfer of Epstein–Barr virus-specific cytotoxic T cells in solid organ transplant patients with posttransplant lymphoproliferative disease Proceedings of the National Academy of Sciences of the United States of America. ,vol. 96, pp. 10391- 10396 ,(1999) , 10.1073/PNAS.96.18.10391
Angela Hui, Kwok-Wai Lo, Peter Teo, Ka-Fai To, Dolly Huang, Genome wide detection of oncogene amplifications in nasopharyngeal carcinoma by array based comparative genomic hybridization. International Journal of Oncology. ,vol. 20, pp. 467- 473 ,(2002) , 10.3892/IJO.20.3.467
Viviana P. Lutzky, Monika Corban, Lea Heslop, Leanne E. Morrison, Pauline Crooks, David F. Hall, William B. Coman, Scott A. Thomson, Denis J. Moss, Novel Approach to the Formulation of an Epstein-Barr Virus Antigen-Based Nasopharyngeal Carcinoma Vaccine Journal of Virology. ,vol. 84, pp. 407- 417 ,(2010) , 10.1128/JVI.01303-09
Daniel T. T. Chua, William I. Wei, Maria P. Wong, Jonathan S. T. Sham, John Nicholls, Gordon K. H. Au, Phase II study of gefitinib for the treatment of recurrent and metastatic nasopharyngeal carcinoma. Head and Neck-journal for The Sciences and Specialties of The Head and Neck. ,vol. 30, pp. 863- 867 ,(2008) , 10.1002/HED.20792