Infection with human H1N1 influenza virus affects the expression of sialic acids of metaplastic mucous cells in the ferret airways.
作者： S. Kirkeby , C.J.M. Martel , B. Aasted
DOI: 10.1016/J.VIRUSRES.2009.05.004
关键词:
摘要: Glycans terminating in sialic acids serve as receptors for influenza viruses. In this study ferrets were infected with virus A/New Caledonia/20/99, and the situ localization of linked α2-3 α2-6 airways was investigated non-infected animals by use acid detecting lectins a monoclonal antibody towards Sialyl-Tn antigen. The goblet cells bronchi from expressed Sialylα2-6Gal glycans, while seromucinous glands submucosa Sialylα2-3Gal glycans. animals, surface epithelial some showed metaplasia antigen: Sialylα2-6GalNAc-O-Thr/Ser. submucosal tracheal these increased expression both Sialylα2-3 Sialylα2-6 epitopes.
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