Carbohydrate determinants in ferret conjunctiva are affected by infection with influenza H1N1 virus.
作者： Svend Kirkeby , Cyril J. M. Martel , Bent Aasted , Henrik Vorum
DOI: 10.3109/02713683.2013.803289
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摘要: AbstractBackground: Carbohydrates often accomplish as cell-surface receptors for microorganisms and influenza virus preferentially binds to sialic acid through the viral haemagglutinin. The may attach not only epithelium in airways, but also surface ocular epithelium.Purpose: To decide if ferrets can be used study induced conjunctivitis evaluate changes conjunctival glycosylation pattern during an attack.Methods: Ferrets were infected with H1N1 via nasal inoculation. situ carbohydrate expressions eyelid sections from 0 10 days after infection was examined using lectin- immunohistochemistry.Results: cells became hypertrophic appearance of both PAS positive PAS + Alcian Blue stained 5–6 binding three detecting lectins investigated: WGA, MAA2 SNA1. While none them epithelial non-infected ferre...
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