A Guide for the Use of the Ferret Model for Influenza Virus Infection.

摘要: As influenza viruses continue to jump species barriers cause human infection, assessments of disease severity and viral replication kinetics in vivo provide crucial information for public health professionals. The ferret model is a valuable resource evaluating virus pathogenicity; thus, understanding the most effective techniques sample collection usage, as well full spectrum attainable data after experimental inoculation in this species, paramount. This especially true scheduled necropsy virus-infected ferrets, standard component evaluation pathogenicity, findings can important regarding pathogenicity that not otherwise available from live animal. In review, we describe range assessed measures model, optimal sample during ferrets. Collectively, critical assessing systemic involvement infection mammals.