Distribution of Adhesion and Toxin Genes in Staphylococcus aureus Strains Recovered From Hospitalized Patients Admitted to the ICU

摘要: Background: Methicillin-resistant Staphylococcus aureus (MRSA) strains are a common cause of emerging nosocomial infections and major public health concern. Objectives: The aim the present study was to determine prevalence MRSA, its antibiotic resistance pattern, virulence gene profiles in hospitalized patients admitted ICUs. Methods: During 6-month period, total 70 S. isolates were collected from 249 ICU five hospitals. In vitro susceptibility testing carried out using Kirby-Bauer disk diffusion method with 16 disks. Molecular detection toxin adhesion genes PCR. Results: All confirmed be MRSA strains. largest number found blood (42.9%) wound (21.4%) samples. MDR pattern detected 71.4% isolates, which obtained Simultaneous seven, six, five, four three drugs 35 (50%), 7 (10%), 8 (11.4%), 11 (15.7%), 2 (2.9%) 5 (7.1%) respectively. frequency spa, fnbB, fnbA, clfB, clfA, can, bbp, ebp, etb, eta, pvl, tst 100%, 75.7%, 74.3%, 78.6%, 71.4%24.3%, 0%, 58.6%, 2.9%, 7.1%, 21.4%, 51.4%, addition, among all examined genes, clfB (78.6%) etb had highest lowest Conclusions: study, we high at hospitals studied. findings emphasized increased containing different probably accompanied by antimicrobial resistance. Infection such worsens clinical outcomes as well morbidity mortality rates