Dynamics of pancreatic cell growth and differentiation during diabetes reversion in STZ-treated newborn rats.

摘要: Cellular processes underlying ontogenesis and regression of streptozotocin (STZ)-induced diabetes in newborn rats were investigated at the most severe stage day 3 after recovery normoglycemia 8 by immunocytochemistry quantitative analysis. A previously unknown endocrine cell type subpopulation (PEPS) was identified. It characterized granule polymorphism, coexpression insulin glucagon immunoreactivity, a proliferative capacity transiently higher than B cells. In STZ-treated 3, mass decreased 14-fold, whereas PEPS cells unaffected. The islet restored to 55.7% 8, with concomitant appearance numerous small islets contiguous ducts. increased 6.9-fold compared 1.8-fold control rats, although capacities remained similar. Proliferation dropped considerably preventing complete rats. STZ-induced neonatal thus stimulates neogenesis close ducts proliferation Those partially differentiated appear be on differentiation pathway stem fully