Biosynthesis of plasma apolipoproteins by rat small intestine without dietary or biliary fat.

摘要: Using two complementary methods developed and applied earlier in rats absorbing triacylglycerols, we have now determined the intestinal contribution of individual plasma apolipoproteins when rate lipid absorption is very low. After all dietary fat was withheld for 16-20 h, intestine produced approximately 50% apolipoprotein A-I (apo-A-I) apo-A-IV, similar to its during absorption. When were fed a fat-free diet 12 days and, addition, biliary diverted from 16 still apo-A-I only slightly less apo-A-IV. Under both conditions reduced absorption, larger proportion intestinally-derived apo-A-IV bypassed mesenteric lymph released directly into venous blood. The apo-B contribution, 16% total fat-fed rats, 5% withheld. Intestinal entirely lymph. Intestine small amounts apo-C little or no apo-E under conditions. results indicate that production by not regulated triacylglycerol transport.