Ginsenosides Rb1 and Rg1 promote proliferation and expression of neurotrophic factors in primary Schwann cell cultures

摘要: Ginsenoside Rb1 (GRb1) and ginsenoside Rg1 (GRg1), two major ingredients in ginseng root, have gained extensive attention because of its neuroprotective properties. Thus far, most the studies on GRb1 GRg1 been focused their effects neurons. The potential beneficial Schwann cells not investigated comprehensively. present study was designed to examine possible effect proliferation expression nerve growth factor (NGF) brain-derived neurotrophic (BDNF) cells. were incubated without or with at different doses. examined by cell counting. secretion NGF BDNF western blotting ELISA. We found that both capable increasing of, Further showed able increase intracellular cyclic AMP (cAMP) level protein kinase A (PKA) activity. Preincubation 10 μM H89 (a PKA inhibitor) significantly inhibited These findings indicate occurs mainly through pathway cultured