17-hydroxy-17-pentafluoroethyl-estra-4,9(10)-diene-11-methylene oxyalkylene aryl derivatives, process for preparation thereof, and use thereof for treatment of diseases
作者： Andrea Rotgeri , Carsten Möller , Wolfgang Schwede , Ulrich Klar , Wilhelm Bone
DOI:
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摘要: The invention relates to 17-hydroxy-17-pentafluoroethylestra-4,9(10)-diene-11-methyleneoxyalkylenearyl derivative of the formula I with progesterone-antagonising action and processes for preparation thereof, use thereof treatment and/or prophylaxis disorders production medicaments disorders, especially fibroids uterus (myomas, uterine leiomyomas), endometriosis, heavy menstrual bleeds, meningiomas, hormone-dependent breast cancers complaints associated menopause, or fertility control emergency contraception.
lens.org 参考文章(67)
Anil Khile, Nitin Pradhan, Narendra Joshi, Novel polymorph form M of mifepristone and process for its preparation ,(2006)
Wolfgang Schwede, Ulrich Klar, Andrea Rotgeri, Wilhelm Bone, Carsten Möller, 17-hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl derivatives, methods for the production thereof and the use thereof for treating diseases ,(2010)
Lucien Nedelec, Jacques Leclaire, Andre Claussner, Daniel Philibert, 19-nor-3-keto steroids ,(1990)
Donald P. Mcdonnell, Brandee L. Wagner, Mixed agonists of the progesterone receptor and assays therefor ,(1997)
L. Michael Kettel, Ana A. Murphy, Joseph F. Mortola, James H. Liu, Andre Ulmann, Samuel S.C. Yen, Endocrine responses to long-term administration of the antiprogesterone RU486 in patients with pelvic endometriosis. Fertility and Sterility. ,vol. 56, pp. 402- 407 ,(1991) , 10.1016/S0015-0282(16)54531-2
Anja Schmidt, Carsten Moeller, Ralf Wyrwa, Ulrike Fuhrmann, Wolfgang Schwede, Andrea Rotgeri, Thomas Andrew Kirkland, Non-steroidal progesterone receptor modulators ,(2007)
Dario Braga, Joel Bernstein, Crystal Polymorphism: Challenges at the Crossroads of Science and Technology John Wiley & Sons, Ltd. pp. 293- 314 ,(2007) , 10.1002/9783527610112.CH11
Ravinder Aggarwal, Ronald R. Stevens, Multi-stage single-drive FOUP door system ,(1999)
Holger Hess-Stumpp, Christa Hegele-Hartung, Henning M. Beier, Claudia Krusche, Use of antigestagens for inhibiting accelerated endometrial maturation during infertility treatment ,(2001)
Gudrun Reddersen, Birgitt Schneider, Alexander Hillisch, Walter Elger, Gerd Schubert, Progesterone receptor modulators with increased antigonadotropic activity for female birth control and hormone replacement therapy ,(2003)