Role of the JAK-STAT Pathway in Bovine Mastitis and Milk Production.
作者： Muhammad Zahoor Khan , Adnan Khan , Jianxin Xiao , Yulin Ma , Jiaying Ma
DOI: 10.3390/ANI10112107
关键词:
摘要: The cytokine-activated Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway is a sequence communications between proteins in cell, it associated with various processes such as cell division, apoptosis, mammary gland development, lactation, anti-inflammation, immunity. involved transferring information from receptors on the surface to nucleus, resulting regulation genes through transcription. 2 (JAK2), signal A B (STAT5 & B), STAT1, cytokine signaling suppressor 3 (SOCS3) are key members JAK-STAT pathway. Interestingly, prolactin (Prl) also uses regulate milk production traits dairy cattle. activation JAK2 STATs has critical role mastitis resistance. upregulation SOCS3 bovine epithelial cells inhibits genes, which promotes development reduces lactational performance In current review, we highlight recent knowledge JAK-STAT, will enhance our ability devise therapeutic strategies for control. Furthermore, review explores
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Lothar Hennighausen, Gertraud W. Robinson, Kay-Uwe Wagner, Xiuwen Liu, Developing a Mammary Gland Is a Stat Affair Journal of Mammary Gland Biology and Neoplasia. ,vol. 2, pp. 365- 372 ,(1997) , 10.1023/A:1026347313096
Christine J. Watson, Stat transcription factors in mammary gland development and tumorigenesis. Journal of Mammary Gland Biology and Neoplasia. ,vol. 6, pp. 115- 127 ,(2001) , 10.1023/A:1009524817155
T. Usman, Y. Wang, C. Liu, X. Wang, Y. Zhang, Y. Yu, Association study of single nucleotide polymorphisms in JAK2 and STAT5B genes and their differential mRNA expression with mastitis susceptibility in Chinese Holstein cattle. Animal Genetics. ,vol. 46, pp. 371- 380 ,(2015) , 10.1111/AGE.12306
Henna Hamadani, Azmat Khan, M Banday, Ifat Ashraf, Nida Handoo, Asma Shah, Ambreen Hamadani, Bovine Mastitis - A Disease of Serious Concern for Dairy Farmers - International Journal of Livestock Research. ,vol. 3, pp. 42- 55 ,(2013) , 10.5455/IJLR.20130213091143
Perrine Roussel, Patricia Cunha, Adeline Porcherie, Wolfram Petzl, Florence B Gilbert, Céline Riollet, Holm Zerbe, Pascal Rainard, Pierre Germon, Investigating the contribution of IL-17A and IL-17F to the host response during Escherichia coli mastitis. Veterinary Research. ,vol. 46, pp. 56- 56 ,(2015) , 10.1186/S13567-015-0201-4
Fred W. Quimby, Steven J. Schwager, Kevin L. Anderson, Ariel L. Rivas, Rubén N. González, Multifactorial relationships between intramammary invasion by Staphylococcus aureus and bovine leukocyte markers. Canadian Journal of Veterinary Research-revue Canadienne De Recherche Veterinaire. ,vol. 71, pp. 135- 144 ,(2007)
Lawrence O Flowers, Howard M Johnson, Mustafa G Mujtaba, Morgan R Ellis, S Mohammed I Haider, Prem S Subramaniam, None, Characterization of a Peptide Inhibitor of Janus Kinase 2 That Mimics Suppressor of Cytokine Signaling 1 Function The Journal of Immunology. ,vol. 172, pp. 7510- 7518 ,(2004) , 10.4049/JIMMUNOL.172.12.7510
Q. Tian, H. R. Wang, M. Z. Wang, C. Wang, S. M. Liu, Lactogenic hormones regulate mammary protein synthesis in bovine mammary epithelial cells via the mTOR and JAK–STAT signal pathways Animal Production Science. ,vol. 56, pp. 1803- 1809 ,(2016) , 10.1071/AN14113
S Li, J M Rosen, Nuclear factor I and mammary gland factor (STAT5) play a critical role in regulating rat whey acidic protein gene expression in transgenic mice. Molecular and Cellular Biology. ,vol. 15, pp. 2063- 2070 ,(1995) , 10.1128/MCB.15.4.2063
Lilian W Waiboci, Chulbul M Ahmed, Mustafa G Mujtaba, Lawrence O Flowers, James P Martin, Mohammed I Haider, Howard M Johnson, None, Both the Suppressor of Cytokine Signaling 1 (SOCS-1) Kinase Inhibitory Region and SOCS-1 Mimetic Bind to JAK2 Autophosphorylation Site: Implications for the Development of a SOCS-1 Antagonist Journal of Immunology. ,vol. 178, pp. 5058- 5068 ,(2007) , 10.4049/JIMMUNOL.178.8.5058