The effects of exercise, ageing and caloric restriction on protein oxidation and DNA damage in skeletal muscle

摘要: Constant generation of free radicals is an accompanying process aerobic metabolism. The interaction metal ion, hydrogen peroxide and amino acid residues proteins results in a variety structural modifications on inactivation proteins. Moderately modified are sensitive to proteolytic degradation, while severely oxidized cross-linked resistant proteolysis. Physiological pathological conditions which alter the delicate balance radical antioxidant defence, including systems, change rate accumulation Moreover, changes protein synthesis degradation could influence oxidatively Oxidative some may be part controlling cells.