Topographic Analysis of the Choriocapillaris in Intermediate Age-related Macular Degeneration

摘要: Purpose To quantitate regional differences in the choriocapillaris (CC) of patients with intermediate age-related macular degeneration (iAMD), using swept-source optical coherence tomography angiography (SS-OCTA) imaging. Design Cross-sectional study. Methods Subjects were imaged SS-OCTA system (PLEX Elite 9000, Carl Zeiss Meditec Inc, Dublin, California, USA). The CC en face images first compensated for signal attenuation caused by drusen structural information from same slab. Subsequently, each eye, 2 generated different OCTA volume scan sets registered and averaged. averaged then exported to ImageJ binarized subsequent quantitative analysis. In addition analysis whole image iAMD eyes, was also performed 3 regions: (1) region, (2) 150-μm-wide ring around border, (3) drusen-free region. Results Thirty eyes (30 patients) 30 healthy controls enrolled. Compared controls, displayed a lower number voids (median interquartile range [IQR]: 2561 2343-2746 vs 2734 2558-2834; P = .013), a greater void average size (median, IQR: 581.9 μm2, 466.1-726.9 μm2 503.8 μm2, 429.1-576.8 μm2; .027), greater total area 26.0%, 22.1%-29.6% 23.8%, 21.2%-26.4%; .038). multiple regression analysis, presence not significantly associated any variables. By contrast, region alterations. evaluation group, both underneath characterized an increased (P = .005 .045, respectively) Conclusions Intermediate AMD demonstrated flow impairment, which co-localizes the area beneath immediately surrounding drusen.