Genomic Epidemiology of the First Wave of SARS-CoV-2 in Italy.
作者： Francesca Di Giallonardo , Sebastian Duchene , Ilaria Puglia , Valentina Curini , Francesca Profeta
DOI: 10.3390/V12121438
关键词:
摘要: Italy was one of the first countries to experience a major epidemic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with >1000 cases confirmed by 1 March 2020. However, virus genome sequence data is sparse and there has been only limited investigation transmission across country. Here, we provide most extensive study date genomic epidemiology SARS-CoV-2 in covering wave infection. We generated 191 new full-length genomes, largely sampled from central (Abruzzo), before, during, after enforcement nationwide "lockdown" (8 March-3 June). These were combined 460 published sequences Italy. Phylogenetic analysis including global revealed multiple independent introductions into Italy, at least 124 instances clusters representing longer chains transmission. Eighteen these emerged before nation-wide lockdown implemented on 8 March, an additional 18 had evidence for between different Italian regions. Extended periods infections up 104 days observed five clusters. In addition, found seven that persisted throughout period. Overall, show how importations important driver
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