Brain Imaging in Fibromyalgia

摘要: Fibromyalgia is a primary brain disorder or result of peripheral dysfunctions inducing alterations, with underlying mechanisms that partially overlap other painful conditions. Although there are methodologic variations, neuroimaging studies propose neural correlations to clinical findings abnormal pain modulation in fibromyalgia. Growing evidences specific differences activations resting states and pain-evoked conditions confirm hyperalgesia impaired inhibitory descending systems, also demonstrate cognitive-affective influences on experiences, leading augmented pain-processing. Functional data activation abnormalities parallel structural gray matter atrophy, alterations intrinsic connectivity networks, variations metabolites levels along multiple pathways. Data from positron-emission tomography, single-photon-emission-computed blood-oxygen-level-dependent, voxel-based morphometry, diffusion tensor imaging, default mode network analysis, spectroscopy enable the understanding fibromyalgia pathophysiology, favor future establishment more tailored treatments.