Lysophosphatidylcholine induces rapid recruitment and activation of macrophages in the adult mouse spinal cord.

摘要: Lysophosphatidylcholine (LPC) can induce rapid breakdown and removal of myelin from the adult mammalian CNS. In this paper we report detailed characterization immune cell response as well changes in expression adhesion molecules permeability blood-brain barrier after microinjection LPC into mouse spinal cord. T cells neutrophils were seen cord 6-12 h injection, but not PBS-injected mice. Mac-1+ monocytes also at 6 12 white gray matter mice injected with PBS significantly greater injections. At later time points induced an increase number activated macrophages that displayed a variety morphologies matter. These present control widespread microglial activation The these microglia reduced drastically 96 injection suggesting they may have transformed phagocytic different morphology. LPC-induced accompanied by significant increases VCAM-1+ ICAM-1+ blood vessels addition, disruption barrier, compared to Therefore, early transient neutrophil likely promote influx followed effective mediate phagocytosis debris.