摘要: Various irregularities in serotonin (5-HT) function have been postulated as causes of affective disorders. Serotonin has related to many the major symptoms depression, e.g. mood, appetite, sleep, activity, and cognitive dysfunction. Interference with 5-HT synthesis or storage shown induce depression vulnerable individuals. Decreased levels 5-hydroxyindoleacetic acid (5-HIAA) cerebrospinal fluid, decreased plasma tryptophan, low tryptophan neutral amino ratio, abnormalities serotonergic indicated by neuroendocrine challenge tests various platelet measures, reported depressed patients. Concentrations 5-HIAA, metabolite plasma, were found be significantly negatively correlated severity measured Hamilton Rating Scale for Depression score specific depressive symptoms, despite fact that 5-HIAA is largely peripheral origin. Blood platelets, which suggested models nerve terminals, a number uptake sites 3H-imipramine binding Antidepressant drugs may act, part, enhancing activity. The deficit occur at any several levels: diminished availability precursor, impaired activity hydroxylase, release uptake, receptor interactions other neurotransmitters.
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