IL-17A Contributes to the Pathogenesis of Endometriosis by Triggering Proinflammatory Cytokines and Angiogenic Growth Factors

摘要: Endometriosis is a chronic, inflammatory disease characterized by the growth of endometrial tissue in aberrant locations outside uterus. Neoangiogenesis or establishment new blood supply one fundamental requirements endometriotic lesion survival peritoneal cavity. IL-17A emerging as potent angiogenic and proinflammatory cytokine involved pathophysiology several chronic diseases such rheumatoid arthritis psoriasis. However, sparse information available context endometriosis. In this study, we demonstrate potential importance pathogenesis The data show differential expression human ectopic lesions matched eutopic endometrium from women with Importantly, surgical removal resulted significantly reduced plasma concentrations. Immunohistochemistry revealed localization primarily stroma samples. vitro stimulation epithelial carcinoma cells, Ishikawa HUVECs significant increase (vascular endothelial factor IL-8), (IL-6 IL-1β), chemotactic cytokines (G-CSF, CXCL12, CXCL1, CX3CL1). Furthermore, promoted tubulogenesis plated on Matrigel dose-dependent manner. Thus, provide first evidence, to our knowledge, that produce via laparoscopic surgery leads reduction systemic levels IL-17A. Taken together, likely important role promoting angiogenesis environment cavity for maintenance endometriosis lesions.