Association analysis of the catechol-o-methyltransferase (COMT), serotonin transporter (5-HTT) and serotonin 2A receptor (5HT2A) gene polymorphisms with obsessive-compulsive disorder
作者： K. Miguita , E. Ikenaga , E. C. Miguel , H. Vallada , I. Meira-Lima
DOI: 10.1046/J.1601-1848.2003.0042.X
关键词:
摘要: Family and twin studies have supported a strong genetic factor in the etiology of obsessive-compulsive disorder (OCD), although precise mechanism inheritance is unclear. Clinical pharmacological implicated serotonergic dopaminergic systems disease pathogenesis. In this cross-sectional study, we examined allelic genotypic frequencies Val-158-Met substitution COMT gene, 44-base pair (bp) length variation regulatory region serotonin transporter gene (5-HTTLPR) T102C C516T variants receptor type 2A (5HT2A) 79 OCD patients 202 control subjects. There were no observed differences allele genotype between groups for COMT, 5HTTLPR 5HT2A polymorphisms. contrast, statistically significant difference controls was on distribution (χ2 = 16.7, 2df, P = 0.0002) (χ2 = 15.8, 1df, P = 0.00007) polymorphism. The results suggest that variant may be one risk factors our sample. However, further using larger samples family based methods are recommended to confirm these findings.
sci-hub.se 参考文章(29)
Ana Gabriela Hounie, Roseli Gedanke Shavitt, Maria Conceição do Rosario-Campos, Euripedes Constantino Miguel Filho, Marcos Tomanik Mercadante, The tic-related obsessive-compulsive disorder phenotype and treatment implications. Advances in Neurology. ,vol. 85, pp. 43- 55 ,(2001)
K. Weissbecker, C. Cruz, H. Nicolini, B. Orozco, B. Camarena, J.R. De la Fuente, D. Sidenberg, J.L. Kennedy, N. King, DRD2, DRD3 and 5HT2A receptor genes polymorphisms in obsessive-compulsive disorder. Molecular Psychiatry. ,vol. 1, pp. 461- 465 ,(1996)
David L Pauls, JP Alsobrook 2nd, Wayne Goodman, Steve Rasmussen, James F Leckman, A family study of obsessive-compulsive disorder. American Journal of Psychiatry. ,vol. 152, pp. 76- 84 ,(1995) , 10.1176/AJP.152.1.76
Kim M. Schindler, M.A. Richter, James L. Kennedy, Michele T. Pato, Carlos N. Pato, Association between homozygosity at the COMT gene locus and obsessive compulsive disorder. American Journal of Medical Genetics. ,vol. 96, pp. 721- 724 ,(2000) , 10.1002/1096-8628(20001204)96:6<721::AID-AJMG4>3.0.CO;2-M
C J McDougle, C N Epperson, L H Price, J Gelernter, Evidence for linkage disequilibrium between serotonin transporter protein gene (SLC6A4) and obsessive compulsive disorder Molecular Psychiatry. ,vol. 3, pp. 270- 273 ,(1998) , 10.1038/SJ.MP.4000391
Maria Cristina Cavallini, Daniela Di Bella, Francesca Siliprandi, Francesca Malchiodi, Laura Bellodi, Exploratory factor analysis of obsessive-compulsive patients and association with 5-HTTLPR polymorphism. American Journal of Medical Genetics. ,vol. 114, pp. 347- 353 ,(2002) , 10.1002/AJMG.1700
John P. Alsobrook, Ada H. Zohar, Marion Leboyer, Nadia Chabane, Richard P. Ebstein, David L. Pauls, Association between the COMT locus and obsessive-compulsive disorder in females but not males. American Journal of Medical Genetics. ,vol. 114, pp. 116- 120 ,(2002) , 10.1002/AJMG.10040
Jeanette Erdmann, Daphne Shimron-Abarbanell, Marcella Rietschel, Margot Albus, Wolfgang Maier, Judith Körner, Brigitta Bondy, Kevin Chen, Jean C. Shih, Michael Knapp, Peter Propping, Markus M. Nöthen, Systematic screening for mutations in the human serotonin-2A (5-HT2A) receptor gene: identification of two naturally occurring receptor variants and association analysis in schizophrenia. Human Genetics. ,vol. 97, pp. 614- 619 ,(1996) , 10.1007/BF02281871
E A Billett, M A Richter, N King, A Heils, K P Lesch, J L Kennedy, Obsessive compulsive disorder, response to serotonin reuptake inhibitors and the serotonin transporter gene Molecular Psychiatry. ,vol. 2, pp. 403- 406 ,(1997) , 10.1038/SJ.MP.4000257
Maria Karayiorgou, Christina Sobin, Maude L. Blundell, Brandi L. Galke, Lubomira Malinova, Pablo Goldberg, Jurg Ott, Joseph A. Gogos, Family-based association studies support a sexually dimorphic effect of COMT and MAOA on genetic susceptibility to obsessive-compulsive disorder Biological Psychiatry. ,vol. 45, pp. 1178- 1189 ,(1999) , 10.1016/S0006-3223(98)00319-9