Estrogen Therapy, Independent of Timing, Improves Cardiac Structure and Function in Oophorectomized mRen2.Lewis Rats

摘要: OBJECTIVE mRen2.Lewis rats exhibit exacerbated increases in blood pressure, left ventricular (LV) remodeling, and diastolic impairment after the loss of estrogens. In this same model, depletion estrogens has marked effects on cardiac biopterin profile concomitant with suppressed nitric oxide release. With respect to establishment overt systolic hypertension oophorectomy (OVX), we assessed timing long-term 17β-estradiol (E2) therapy myocardial function, structure, system. METHODS OVX (n = 24) or sham operation (Sham; n 13) was performed 4-week-old female rats. After randomization, received E2 immediately (OVX + E2-early; 7), at 11 weeks age E2-late; 8), no all (OVX; 9). RESULTS E2-early associated lower body weight, less hypertension-related decreased LV filling pressure compared without supplementation. E2-late similarly attenuated adverse ovarian hormone tissue Doppler-derived pressures perivascular fibrosis, significantly improved relaxation mitral annular velocity (e'). Early late exposures dihydrobiopterin, but only yielded significant nitrite concentrations. CONCLUSIONS Although there are some similarities between treatments relation preservation function structure OVX, lusitropic potential is most consistent The cardioprotective independent may have occurred through regulation biopterins production.