Elevated Plasma Growth Differentiation Factor-15 Correlates with Lymph Node Metastases and Poor Survival in Endometrial Cancer

摘要: Purpose: The study objective was to investigate and validate plasma growth differentiation factor-15 (GDF-15) as a predictor of lymph node metastasis poor prognosis in primary endometrial cancer. Experimental Design: Plasma samples from 510 women treated for cancer investigation cohort ( n = 44) secondary validation 466) were analyzed GDF-15. healthy premenopausal 20) postmenopausal women, with borderline 43), benign 144), malignant ovarian tumors 125) used comparison. Results: Median GDF-15 concentration the group elevated (1,077 ng/L) compared pre- controls (590 684 (591 or (718 ng/L; all P ≤ 0.001). High also an independent disease-specific recurrence-free survival. Conclusions: Based on findings indicated set confirmed large set, we report first time biomarker phenotype, including presence reduced Its applicability metastatic nodes monitoring treatment needs be further studied. Clin Cancer Res; 17(14); 4825–33. ©2011 AACR .