Role of protein kinases in neurodegenerative disease: cyclin-dependent kinases in Alzheimer's disease.
作者： Edward, A. Monaco III
DOI: 10.2741/1516
关键词:
摘要: Cyclin-dependent kinases (Cdks) are serine/threonine that regulate a number of cellular processes including the cell cycle and neuronal differentiation. Accumulating evidence indicates two distinct Cdk pathways may have role in loss is responsible for Alzheimer's disease. One pathway involves aberrant reactivation cycle, process believed to be incompatible with function. A second dysregulation Cdk5, member this kinase family no known functions, but prominently expressed postmitotic neurons. Reports supporting involvement both plentiful, story not yet complete. In particular, difficulties incorporating extended latency AD into model approaches persist. Despite this, theory Cdks involved pathogenesis has generated considerable interest.
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