Migration of cultured vascular cells in response to plasma and platelet-derived factors
作者： H. Antoniades , B.R. Zetter , L.R. Bernstein
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摘要: Phagokinetic migration of cultured vascular cells was tested in response to human platelet-rich serum ('serum') and platelet-poor plasma ('plasma'). The cell types included bovine aortic endothelial cells, umbilical vein haemangiomal capillary adrenal microvascular pericytes, smooth muscle cells. Human stimulated a significant increase the rate for all five types. migrate but had no effect on pericytes or Highly purified platelet-derived growth factor (PDGF) dose-dependent causing 50% phagokinetic track area relative controls. Neither pericyte nor by PDGF. Rabbit antiserum PDGF completely blocked induced either 10% 1 ng/ml pure Purified platelet IV (PF4) not Sheep PF4 microgram/ml PF4. These results indicate that is primary responsible critical required induce pericytes. Other factors present both control
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