Fuzzy clustering demonstrates that codon 72 SNP rs1042522 of TP53 gene associated with HNSCC but not with prognoses

摘要: It is estimated that 7.6 million people will die as a consequence of head and neck squamous cell carcinoma (HNSCC). Genetic predisposition has emerged an important risk factor in the development prognosis HNSCC. Considering this, aim current study to assess whether codon 72 SNP TP53 gene (rs1042522) associated with increased odds ratio developing HNSCC or worse patients Analysis rs1042522 control individuals. Differences between case groups were determined using chi-squared tests. Multivariate analysis was performed evaluate Fussy C Means Clustering cluster for survival analyses. Time calculated Kaplan-Meier estimator comparing this log rank test. Statistical significance set at p < 0.05. A total 71.4 % Arg/Arg genotype from patients, while only 28.6 found group. Logistic regression demonstrated genotype, smoking, alcohol consumption increase No association polymorphism P53 expression. prognoses observed. This identified individuals carrying arginine allele have However, no expression