Prion protein is associated with a worse prognosis of head and neck squamous cell carcinoma.
作者： André Luiz Sena Guimarães , Alfredo Maurício Batista de Paula , Carlos Alberto de Carvalho Fraga , Lucyana Conceição Farias , Sabrina Ferreira de Jesus
DOI: 10.1111/JOP.13188
关键词:
摘要: Background Head and neck squamous cell carcinoma (HNSC) etiopathogenesis remains unclear, the biological changes with activation of heat shock proteins (HSPs) prion protein (PRNP) promoted by hypoxia in HNSC are undetermined. Objective This study investigates hypoxia's effect lymph node metastasis PRNP expression its main partners. Methods The combined a theoretical/cell culture case-control study. First, bioinformatics were performed. A was performed second step comparing patients without metastasis. Analyses Cancer Genome Atlas (TCGA) data source validate theory global population Results Bioinformatics analysis suggests that hypoxia-inducible factor-1α (HIF1A) is associated HSPA4, HSP90AA1, expression. TCGA hypothesis higher related to metastases low survival. Herein, demonstrated muted did not respond hypoxia. Conclusions Our results collectively provide first evidence promotes progression through upregulation HIF1A. findings may molecular basis for promoting Role progression.
sci-hub.st 参考文章(33)
Ugo Borges Pinheiro, Carlos Alberto de Carvalho Fraga, Danilo Cangussu Mendes, Lucyana Conceição Farias, Cláudio Marcelo Cardoso, Christine Mendes Silveira, Marcos Flávio Silveira Vasconcelos D̕Angelo, Kimberly Marie Jones, Sérgio Henrique Souza Santos, Alfredo Maurício Batista de Paula, André Luiz Sena Guimarães, Fuzzy clustering demonstrates that codon 72 SNP rs1042522 of TP53 gene associated with HNSCC but not with prognoses Tumor Biology. ,vol. 36, pp. 9259- 9265 ,(2015) , 10.1007/S13277-015-3677-7
Andr� Sena Guimar�es, HPV-16/18 detection does not affect the prognosis of head and neck squamous cell carcinoma in younger and older patients Oncology Letters. ,vol. 3, pp. 945- 949 ,(2012) , 10.3892/OL.2012.588
Jin-Young Park, Jae-Kyo Jeong, Ju-Hee Lee, Ji-Hong Moon, Sung-Wook Kim, You-Jin Lee, Sang-Youel Park, Induction of cellular prion protein (PrPc) under hypoxia inhibits apoptosis caused by TRAIL treatment Oncotarget. ,vol. 6, pp. 5342- 5353 ,(2015) , 10.18632/ONCOTARGET.3028
C PARR, M CUMMINGS, Data sharing in ecology and evolution Trends in Ecology and Evolution. ,vol. 20, pp. 362- 363 ,(2005) , 10.1016/J.TREE.2005.04.023
Hyo Geun Choi, Jin-Soo Kim, Ki Hwan Kim, Kwang Hyun Kim, Myung-Whun Sung, Ji-Young Choe, Ji Eun Kim, Young Ho Jung, Expression of hypoxic signaling markers in head and neck squamous cell carcinoma and its clinical significance. European Archives of Oto-rhino-laryngology. ,vol. 272, pp. 219- 228 ,(2015) , 10.1007/S00405-014-2954-1
JINBAO ZONG, CHANGYUAN WANG, BIN LIU, MINGJUN LIU, YONGXIAN CAO, XIUFANG SUN, YUAN YAO, GUIRONG SUN, Human hsp70 and HPV16 oE7 fusion protein vaccine induces an effective antitumor efficacy. Oncology Reports. ,vol. 30, pp. 407- 412 ,(2013) , 10.3892/OR.2013.2445
AMB De Paula, LR Souza, LC Farias, GTB Correa, CAC Fraga, NB Eleuterio, ACO Silveira, FBG Santos, DS Haikal, ALS Guimarães, RS Gomez, Analysis of 724 cases of primary head and neck squamous cell carcinoma (HNSCC) with a focus on young patients and p53 immunolocalization Oral Oncology. ,vol. 45, pp. 777- 782 ,(2009) , 10.1016/J.ORALONCOLOGY.2008.11.015
Kirsten Lauber, Nikko Brix, Anne Ernst, Roman Hennel, Julia Krombach, Heike Anders, Claus Belka, Targeting the heat shock response in combination with radiotherapy: Sensitizing cancer cells to irradiation-induced cell death and heating up their immunogenicity. Cancer Letters. ,vol. 368, pp. 209- 229 ,(2015) , 10.1016/J.CANLET.2015.02.047
M H Lopes, T G Santos, B R Rodrigues, N Queiroz-Hazarbassanov, I W Cunha, A P Wasilewska-Sampaio, B Costa-Silva, F A Marchi, L F Bleggi-Torres, P I Sanematsu, S H Suzuki, S M Oba-Shinjo, S K N Marie, E Toulmin, A F Hill, V R Martins, Disruption of prion protein-HOP engagement impairs glioblastoma growth and cognitive decline and improves overall survival. Oncogene. ,vol. 34, pp. 3305- 3314 ,(2015) , 10.1038/ONC.2014.261
Gregg L. Semenza, Targeting HIF-1 for cancer therapy Nature Reviews Cancer. ,vol. 3, pp. 721- 732 ,(2003) , 10.1038/NRC1187