The looped heart does not save energy by maintaining the momentum of blood flowing in the ventricle.

摘要: Previous studies suggested that the reconstruction or maintenance of physiological blood flow paths in heart is important to obtain a good outcome following cardiac surgery, but this concept has no established theoretical foundation. We developed multiscale, multiphysics simulator, based on finite element method, and compared hemodynamics ventricles with nonphysiological paths. found path did not have an energy-saving effect facilitated separation outflow inflow paths, so avoiding any mixing blood. The work performed by ventricular wall was comparable at slower faster rates (physiological vs. nonphysiological, 0.864 0.874 J, rate = 60 beats/min; 0.599 0.590 100 beats/min), indicating chiral asymmetry mammalian minimal functional merit. At lower rates, coming first beat cleared almost completely ninth both models. However, high such complete clearance observed only model, whereas 27.0% remained model. This multiscale simulator provided detailed information mechanics dynamics could be useful tool physiology.