Paraoxonase 1 (PON1) gene-108C>T and p.Q192R polymorphisms and arylesterase activity of the enzyme in patients with dementia.
作者： Małgorzata Ewa Bednarska-Makaruk , Tomasz Krzywkowski , Alla Graban , Wanda Lipczyńska-Łojkowska , Anna Bochyńska
关键词:
摘要: Paraoxonase 1 (PON1) activity was determined using phenylacetate as substrate (arylesterase activity) in 304 individuals with dementia--136 recognised probable Alzheimer's disease (AD), 64 dementia of vascular origin (VaD) and 104 mixed (MD) 129 persons without symptoms a good general health. -108C>T polymorphism the PON1 gene promoter p.Q192R coding region were identified. significantly lower demented patients compared controls particularly neurodegenerative character (AD MD). The prevalence PON1-108T allele carriers higher AD group than controls. frequencies genotypes did not differ between investigated groups. An association rare T-R haplotype dementia, type, found. Multivariate regression analysis showed significant polymorphisms. influence only -108C>T, but also on arylesterase observed. One has to admit that this kind does preclude interference enzyme activity. It could be concluded plays an additional role development. seems however dominating risk.
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