Antinociceptive effects of butorphanol, buprenorphine, or both, administered intramuscularly in cats.

摘要: Objective—To characterize the antinociceptive action of IM-administered butorphanol, buprenorphine, or a combination both by use thermal threshold method in cats. Animals—2 male and 4 female domestic Procedures—In controlled, masked, randomized, crossover study design, thresholds were measured threshold–testing device developed for Each cat received treatments 1 week apart, consisting 2 simultaneous IM injections random order (butorphanol-saline [0.9% NaCl] solution, buprenorphine-saline butorphanol-buprenorphine, saline solution-saline solution). The tester was unaware treatment given. Thermal prior to injection, at intervals up 12 hours, 22 hours after injection. Results—There no significant change over time solution administration. All 3 opioid groups had increases threshold, compared with pretreatment values (butorphanol, fro...