Obstructive sleep apnea syndrome: the effect of diabetes and autonomic neuropathy.

摘要: Several studies indicate an association between obstructive sleep apnea syndrome (OSAS) and diabetic autonomic neuropathy (DAN). Observed frequency of OSAS in patients with DAN varies 26% 30%. Excessive daytime sleepiness is one the major clinical symptoms disordered breathing. Diabetics might have abnormal control respiration during sleep, probably resulting a reduced sleepiness. We investigated impact on (e.g., sleepiness, measured by Epworth Sleepiness Scale, ESS) suspected OSAS. examined 196 (52 female, 144 male, mean age 58.7 yrs, BMI 30.57 kg/m2). All underwent overnight polysomnography were tested for method measuring heart rate variabilty response to Valsalva maneuver, standing deep breathing using computerized data analysis system. Eighty subjects: 52 DAN-, 28 DAN+; 116 subjects without diabetes: 101 (AN), 15 AN+. The group diabetics DAN+ had apnoea/hypopnea index (AHI) 38.6/h, oxygen desaturation: 77.5%, ESS-Score: 9.86. Diabetic DAN-: AHI:30.4/h, 79.3%, ESS-Score 9.73. Defining as AHI>5/h ESS-Score>9, 46% positive, whereas DAN- 61% met criteria (non-diabetic AN 50.5%; AN: 60%). Although lowest percentage OSAS, statistical showed no significance comparisons DAN-/DAN+ or diabetic/non-diabetic. In conclusion, although this study did not give evidence, there reason assume that show fewer than those it. examination be indicated even excessive because elevated cardiovascular risk.