Sleep-disordered breathing in nonobese diabetic subjects with autonomic neuropathy.

摘要: To assess the occurrence and nature of sleep-disordered breathing (SDB) in 26 adult, nonobese diabetics (18 with autonomic neuropathy (DAN+) (age 45 (41–50) yrs; body mass index (BMI) 24.1 (22–26) kg·m −2 ) eight without (DAN−) (35–55) BMI 24.8 (23–26) )) overnight full sleep studies measurements central peripheral carbon dioxide (CO 2 chemosensitivity were performed. DAN+ divided two subgroups, according to presence (DAN+PH+; n=10) or absence (DAN+PH−; n=8) postural hypotension. Ten normal subjects studied as controls 42 (36–48) 24.4 (23–25) ). In contrast DAN− controls, who did not show SDB, five (four DAN+PH− one DAN+PH+) had an apnoea/hypopnoea ≥10 four (two apnoea ≥5. All events obstructive, occurring mainly during rapid eye movement (REM) sleep. exhibited a mean lowest oxygen saturation . Both subgroups showed marked reduction CO chemosensitivity. conclusion, adult neuropathy, independent severity their dysautonomy, have obstructive frequency >30%. A decrease prevents hypotension from experiencing posthyperventilatory apnoea, despite increased hypercapnic drive.