Cytotoxic T-cell activity antagonized by naturally occurring HIV-1 Gag variants

摘要: Most asymptomatic individuals infected with HIV-1 have a cytotoxic T lymphocyte (CTL) response to the virus Gag proteins which can be demonstrated in vitro. Epitopes been mapped p17 and p24 restricted by HLA-B8 (p17-3 p24-13) -B27 (p24-14). Viruses isolated from patients who make CTL responses these peptides vary within genetic sequences encoding epitopes some mutations lead reduction killing activity This was attributed either failure of variant epitope bind major histocompatibility complex class I or T-cell receptors presented peptide. But peptide variants I-restricted cause 'antagonism', that is, presence (in form peptide) inhibits normal lysis targets presenting original epitope. mirrors similar findings II-restricted systems. Here we report naturally occurring forms p17-3, p24-13 p24-14 may antagonism lines derived same individuals. The effect is present if are synthetic when they processed full-length expressed recombinant vaccinia constructs replicating HIV.