Amelioration of ischemia- and reperfusion-induced myocardial injury by the selective estrogen receptor modulator, raloxifene, in the canine heart.

摘要: Abstract Objectives We sought to investigate whether raloxifene reduces ischemia-reperfusion injury and what mechanisms are involved in the cardioprotective effects. Background Estradiol-17-beta myocardial infarct size injury. Raloxifene, a selective estrogen receptor modulator, demonstrates immediate coronary artery vasorelaxing Methods The model included anesthetized open-chest dogs after 90-min occlusion of left anterior descending (LAD) subsequent 6-h reperfusion. Raloxifene and/or other drugs were infused into LAD from 10 min before 1 h reperfusion without an period. Results Infarct was reduced (5 μg/kg per min) group compared with control (7.2 ± 2.5% vs. 40.9 3.9% area at risk, p Conclusions These data demonstrate that by dependent on NO opening KCa channels canine hearts. Deactivation p38 MAP kinase myeloperoxidase may be cellular cardioprotection.